DNA Me Guidebook - Jessica Costello

TAMARA RENEE

DNA Me Program
PREPARED FOR
Jessica Costello
January 19, 2026

"Your personalized roadmap to health, based on your unique genetic blueprint."

This DNA Wellness Report is not intended to diagnose, treat, or cure any medical condition. It is for educational purposes only and is based on your genetic blueprint. Always consult with your healthcare provider before making any health-related decisions.
SECTION 01

Overview of Your Genetic Test Results

HEIGHT
65"
WEIGHT
150 lbs
BMI
24.96

Status: Within Recommended Range (18.5-25.0)

Your Ideal Weight Range

SMALL FRAME
114 lbs
MEDIUM FRAME
127 lbs
LARGE FRAME
139 lbs

Metabolism Blueprint: Optimal Blend

Your genetic test results suggest you will benefit from a nutrition plan that includes carbohydrates, fats, and proteins in specific proportions.

SECTION 02

Overall Metabolism

Thyroid Function (DIO1) Somewhat Decreased T3:T4 Ratio

Analysis: Your genetic results suggest a possible moderate reduction in the efficiency of thyroid hormone metabolism in peripheral tissues. The DIO1 gene variant you possess is associated with decreased conversion of thyroxine (T4) into its more active form (T3).

Suggestion: This reduced conversion may result in less thyroid activity in target tissues, potentially predisposing you to a slower metabolism.

Metabolic Syndrome Assessment

Risk Profile: Below Average

Your genetic factors indicate that you have a below average genetic tendency to develop metabolic syndrome compared with the population in general. Lifestyle choices (exercise, healthy eating) remain key elements in maintaining this status.

SECTION 03

Nutrition Plan Based on Genetics

Program: Optimal Blend
Carbs: 55%
Proteins: 20%
Fats: 25%

Your Genetic Drivers

APOA2 (TC)

Normal HDL levels. You tend to have normal expression of this gene and respond well to physical activity and caloric reduction.

ADRB2 (CC)

Normal risk of gaining excessive weight; likely to respond well to diet and physical activities.

FTO (TT)

Favorable for maintaining healthy weight. This genotype does not adversely affect the tendency to gain weight based on intake of fats or carbs.

FABP2 (GA)

Increased intestinal absorption of dietary fat. Depending on other factors, this can lead to a greater risk for excess weight gain.

GIPR (CT)

May benefit from limiting the amount of fats and carbohydrates in the diet.

IL6 (CG)

Higher inflammation risk. You may benefit from replacing saturated fats with unsaturated fats to help lower inflammation.

IRS1 (TT)

Can reduce insulin signaling. Benefit from dietary adjustments with a focus on lower glycemic index carbohydrates and unsaturated fats.

LIPC (GG & CT)

Higher hepatic lipase activity generally, though the second variant suggests reduced activity. Extra emphasis should be placed on unsaturated fat sources and low glycemic index carbs.

PPARG (CC)

Increased sensitivity to the quality of dietary fat; higher risk of being overweight.

TCF7L2 (AG)

Decreased insulin production. May experience improved glycemic control with a diet including lower levels of fat.

Hydration & Alcohol

  • Water: 9 cups (approx. 2.2 liters) per day.
  • Alcohol: Your genetic test results are consistent with normal metabolism, but alcohol can still negatively affect fat metabolism. Moderation is essential.
SECTION 04

Digestion and Absorption

Gluten Tolerance (HLA) Slightly Higher Inflammation

Your genotype is associated with a slightly elevated tendency toward inflammation in response to gluten. If you experience symptoms, consult a healthcare provider.

Lactose Digestion (MCM6) Normal Digestion

Associated with the ability to fully process lactose throughout adulthood due to continued production of lactase.

B12 Absorption (FUT2) Moderately Efficient

You absorb B12 moderately well. Maintain intake via poultry, meat, fish, and dairy. Supplementation may be helpful.

SECTION 05

Fitness Program Based on Genetics

Exercise Recommendations

Intensity: Moderate Intensity (MET value 3-6)

Weekly Goal: 15-20 MET-hours per week

Recommendation: Your body should respond well to moderate intensity activities.

Your Competitive Edge

Performance Profile: Intermediate (Strength and Endurance)

Your genotype is consistent with an increased proportion of fast-twitch muscle fibers. You will perform well at activities which emphasize strength and intense bursts of activity (sprinting, tennis, power lifting).

Resistance Training

  • Load: Heavier weights
  • Reps: 5-10 repetitions per set
  • Strategy: Your fast-twitch dominance means you may benefit most from heavier loads for shorter periods. Allow 24-48 hours rest between workouts.

Fitness Genes

FTO (TT): Normal risk for weight gain; responds well to diet and exercise.

ADRB3 (TT): May tend to lower the intensity of exercise required to maintain healthy weight.

ACE (AG): Tends to increase the intensity of exercise required to effectively manage weight.

ENOS (TT): May have an increased oxygen supply to muscles in response to exercise.

ACTN3 (CC): May improve success in activities requiring sprint or power performance (explosive power).

ADRB2 (AA): May demonstrate greater reductions in BMI and body fat in response to endurance training.

SECTION 06

Genetics and Healthy Behavior

Hunger & Satiety (FTO) Normal

Consistent with normal levels of hunger-stimulating hormone ghrelin. You may expect a normal level of difficulty with appetite control.

Eating for Pleasure (DRD2) Normal

Correlated with normal dopamine receptor density. This gene does not increase your difficulty in managing diet.

Taste Preference (TAS2R38) Supertaster

Associated with increased sensitivity to bitter compounds (may avoid broccoli, cabbage) and a preference for sweet foods. Search for fruit/vegetable choices that are pleasing to your palate.

Sugar Cravings (GLUT2) Normal Tendency

Associated with a normal tendency to crave sugars.

Mood & Food (MTHFR) Intermediate

Moderately reduced enzyme activity. May result in lower levels of serotonin and dopamine. Diet rich in folate (greens, fruits, beans) and regular exercise is recommended.

Circadian Rhythm (CLOCK) Favorable

Correlated with normal circadian rhythm, optimum sleep pattern, and morning eating preference.

Neurotransmitter Balance (COMT) Moderately Favorable

Emphasize high-quality proteins and high fiber vegetables. Avoid sugar and alcohol.

SECTION 07

Fascia + DNA: The Aging Backward Combo

Understanding your body goes beyond just genetics. The health of your fasciaβ€”the connective tissue that surrounds your muscles and organsβ€”plays a critical role in how you look and feel.

The Fascia Strategy

Based on your IL6 marker (Inflammation Risk), maintaining hydrated, flexible fascia is vital to reduce systemic inflammation and support your genetic predispositions.

Key Benefits

  • Skin Health: Fascia supports the skin structure. Keeping it healthy reduces the appearance of cellulite.
  • Hormonal Balance: Fascia acts as a communication highway for your body's signals.
  • Lymphatic Flow: Tight fascia can block lymph nodes, leading to swelling and toxin buildup.
SECTION 08

TR's Food Quality Cheat Sheet

Based on the Optimal Blend Program.

GRAINS
5
VEGGIES
5
FRUIT
1
PROTEIN
3
FATS
4
Recommended Sources
  • Vegetables: Tomato juice, Raw vegetables, Cooked vegetables (Avoid bitter if sensitive).
  • Fruit: Melon cubes, Fresh fruit, Dried fruit.
  • Grains/Starches: Whole wheat tortilla, Brown rice, Beans/Lentils, Whole wheat bread.
  • Meats: Meat/Poultry/Fish, Egg, Peanut butter.
  • Dairy: Yogurt, Reduced fat milk.
  • Oils/Fats: Olive oil, Nuts, Avocado.
SECTION 09

Sample Day of Eating: Weight Loss

  • Daily Target: 1,281 Calories
  • Program: Optimal Blend (55% C / 20% P / 25% F)
  • Focus: Gluten-Aware & Bitter-Sensitive
Breakfast
  • 1 Egg (1 Meat serving)
  • 1 slice Gluten-Free Toast (1 Grain serving)
  • 1 cup Reduced Fat Milk (1 Dairy serving)
Snack
  • 1 cup Melon cubes (1 Fruit serving)
  • 10 Walnuts (1 Fat serving)
Lunch
  • Grilled Chicken Breast 1 oz (1 Meat serving)
  • 1 cup Cooked Brown Rice (2 Grain servings)
  • 1 cup Spinach Salad + Β½ cup Cucumber (2 Veggie servings - non-bitter selection)
  • 1 tsp Olive Oil Dressing (1 Fat serving)
Dinner
  • Baked Salmon 1 oz (1 Meat serving)
  • 1 cup Cooked Quinoa (2 Grain servings)
  • 1.5 cups Roasted Sweet Peppers & Carrots (3 Veggie servings - non-bitter selection)
  • 1 cup Plain Yogurt (1 Dairy serving)
  • 2 tsp Olive Oil (for cooking) (2 Fat servings)
SECTION 10

Sample Day of Eating: Maintenance

  • Daily Target: 1,645 Calories
  • Status: Moderately Active
  • Focus: Gluten-Aware & Bitter-Sensitive
Breakfast
  • 1 Egg (1 Meat serving)
  • 1 cup Gluten-Free Oats (2 Grain servings)
  • 1 cup Reduced Fat Milk (1 Dairy serving)
  • 1 tsp Butter or Ghee (1 Fat serving)
Snack
  • 3 cups Plain Popcorn (1 Grain serving)
  • 1 small Fresh Apple (1 Fruit serving)
  • 10 Almonds (1 Fat serving)
Lunch
  • Turkey Breast 1 oz (1 Meat serving)
  • 1.5 cups Cooked Brown Rice (3 Grain servings)
  • 1 cup Mixed Greens (Spinach/Lettuce) (1 Veggie serving)
  • Β½ cup Sliced Cucumber (1 Veggie serving)
  • 2 tsp Olive Oil Dressing (2 Fat servings)
Dinner
  • Grilled Fish 2 oz (2 Meat servings)
  • 1.5 cups Cooked Beans/Lentils (3 Grain servings)
  • 1.5 cups Steamed Green Beans & Carrots (3 Veggie servings - non-bitter selection)
  • 1 cup Yogurt (1 Dairy serving)
  • 1 tsp Olive Oil (1 Fat serving)

TR's Golden Rule

Consistency over perfection. Your genes don't change, but your expression of them does based on your daily choices.

SECTION 11

TR's Favorites - Health & Beauty Must-Haves

Pro Tip

These tools are curated to support your specific needs for Fascia recovery and inflammation reduction (IL6/HLA markers).

  • Red Light & Infrared Therapy
  • Fascia Tools & Sculpting Devices
  • Infrared Sauna & Prepping Fascia Devices
  • Fascia & Recovery Tools
  • Serums & Skin Oils
  • Beauty Sleep Support
  • Bone Broth & Recovery
  • Healthy Living + Living Beautiful Devices

Your 45-Day Radiance Challenge

Submit your before photos now and your after photos at 45 days.

How to take photos
  • Wear the same clothing each time
  • Stand tall with arms relaxed by your sides
  • Take front, side, and back views

Your Reward

You'll receive a special gift from Tamara Renee because your consistency deserves to be celebrated.

Your Next Steps

Contact Tamara Renee

Phone: 619-653-9656

Email: tr@tamararenee.com

Website: www.tamararenee.com

TAMARA RENEE

FASCIA SCULPT & CO.

© 2026 Tamara Renee. All Rights Reserved.

The information provided in this report is for educational purposes only and is not intended to diagnose, treat, or cure any medical condition.
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